STAT6

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Signal transducer and activator of transcription 6, interleukin-4 induced
信号转导及转录激活蛋白6,白介素-4诱导
有效结构
PDB 直系同源检索:PDBe, RCSB
标识
代号 STAT6; D12S1644; IL-4-STAT; STAT6B; STAT6C
扩展标识 遗传学601512 鼠基因103034 同源基因2373 ChEMBL英语ChEMBL: 5401 GeneCards: STAT6 Gene
RNA表达模式
PBB GE STAT6 201331 s at tn.png
PBB GE STAT6 201332 s at tn.png
更多表达数据
直系同源体
物种 人类 小鼠
Entrez 6778 20852
Ensembl ENSG00000166888 ENSMUSG00000002147
UniProt P42226 P52633
mRNA序列 NM_001178078 NM_009284
蛋白序列 NP_001171549 NP_033310
基因位置 Chr 12:
57.49 – 57.53 Mb
Chr 10:
127.64 – 127.66 Mb
PubMed查询 [1] [2]

信号转导及转录激活蛋白6英语:Signal transducer and activator of transcription 6STAT6)是一种由人类基因STAT6 编码的转录因子[1][2]


相互作用[编辑]

STAT3能与下列蛋白質发生交互作用

EP300,[3] CREB-binding protein,[3][4] NFKB1,[5] Nuclear receptor coactivator 1,[4][6] IRF4[7]SND1[8]

另见[编辑]

参考文献[编辑]

  1. ^ Leek JP, Hamlin PJ, Bell SM, Lench NJ. Assignment of the STAT6 gene (STAT6) to human chromosome band 12q13 by in situ hybridization. Cytogenet. Cell Genet. 1997, 79 (3–4): 208–9. PMID 9605853. doi:10.1159/000134723. 
  2. ^ Hou J, Schindler U, Henzel WJ, Ho TC, Brasseur M, McKnight SL. An interleukin-4-induced transcription factor: IL-4 Stat. Science. September 1994, 265 (5179): 1701–6. PMID 8085155. doi:10.1126/science.8085155. 
  3. ^ 3.0 3.1 McDonald, C; Reich N C. Cooperation of the transcriptional coactivators CBP and p300 with Stat6. J. Interferon Cytokine Res. (UNITED STATES). July 1999, 19 (7): 711–22. ISSN 1079-9907. PMID 10454341. doi:10.1089/107999099313550. 
  4. ^ 4.0 4.1 Litterst, C M; Pfitzner E. Transcriptional activation by STAT6 requires the direct interaction with NCoA-1. J. Biol. Chem. (United States). Dec 2001, 276 (49): 45713–21. ISSN 0021-9258. PMID 11574547. doi:10.1074/jbc.M108132200. 
  5. ^ Shen, C H; Stavnezer J. Interaction of stat6 and NF-kappaB: direct association and synergistic activation of interleukin-4-induced transcription. Mol. Cell. Biol. (UNITED STATES). June 1998, 18 (6): 3395–404. ISSN 0270-7306. PMC 108921. PMID 9584180. 
  6. ^ Litterst, Claudia M; Pfitzner Edith. An LXXLL motif in the transactivation domain of STAT6 mediates recruitment of NCoA-1/SRC-1. J. Biol. Chem. (United States). September 2002, 277 (39): 36052–60. ISSN 0021-9258. PMID 12138096. doi:10.1074/jbc.M203556200. 
  7. ^ Gupta, S; Jiang M; Anthony A; Pernis A B. Lineage-specific modulation of interleukin 4 signaling by interferon regulatory factor 4. J. Exp. Med. (UNITED STATES). Dec 1999, 190 (12): 1837–48. ISSN 0022-1007. PMC 2195723. PMID 10601358. doi:10.1084/jem.190.12.1837. 
  8. ^ Yang, Jie; Aittomäki Saara; Pesu Marko; Carter Kara; Saarinen Jussi; Kalkkinen Nisse; Kieff Elliott; Silvennoinen Olli. Identification of p100 as a coactivator for STAT6 that bridges STAT6 with RNA polymerase II. EMBO J. (England). September 2002, 21 (18): 4950–8. ISSN 0261-4189. PMC 126276. PMID 12234934. doi:10.1093/emboj/cdf463. 

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外部链接[编辑]